Co‐consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants

• Main Authors: John D. Clarke (Author), Sabrina M. Judson (Author), Dan‐Dan Tian (Author), Trevor O. Kirby (Author), Rakshit S. Tanna (Author), Adrienn Matula‐Péntek (Author), Miklós Horváth (Author), Matthew E. Layton (Author), John R. White (Author), Nadja B. Cech (Author), Kenneth E. Thummel (Author), Jeannine S. McCune (Author), Danny D. Shen (Author), Mary F. Paine (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Green tea is a popular beverage worldwide. The abundant green tea catechin (−)‐epigallocatechin gallate (EGCG) is a potent in vitro inhibitor of intestinal UDP‐glucuronosyltransferase (UGT) activity (Ki ~2 μM). Co‐consuming green tea with intestinal UGT drug substrates, including raloxifene...