Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Role of Calcium/Calmodulin-Dependent Protein Kinases in Ischemic Neuronal Death

• Glavni autori: Shigetoshi Yano (Autor), Motohiro Morioka (Autor), Jun-ichi Kuratsu (Autor), Kohji Fukunaga (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2005-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Excessive elevation of intracellular calcium level seems to be a trigger of ischemic neuronal injury. Calcium/calmodulin (CaM)-dependent protein kinase kinase (CaM-KK) is an upstream kinase for CaM kinase IV (CaM-KIV) that was reported to prevent apoptosis through phosphorylation of CREB (cyclic AMP...