Enhancing the Antipsychotic Effect of Risperidone by Increasing Its Binding Affinity to Serotonin Receptor via Picric Acid: A Molecular Dynamics Simulation

• Main Authors: Majid Alhomrani (Author), Walaa F. Alsanie (Author), Abdulhakeem S. Alamri (Author), Hussain Alyami (Author), Hamza Habeeballah (Author), Heba A. Alkhatabi (Author), Raed I. Felimban (Author), John M. Haynes (Author), Sonam Shakya (Author), Bassem M. Raafat (Author), Moamen S. Refat (Author), Ahmed Gaber (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to assess the utility of inexpensive techniques in evaluating the interactions of risperidone (Ris) with different traditional π-acceptors, with subsequent application of the findings into a Ris pharmaceutical formulation with improved therapeutic properties. Molecular dock...