Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia

• Main Authors: Nils Bögeholz (Author), Paul Pauls (Author), Dirk G. Dechering (Author), Gerrit Frommeyer (Author), Joshua I. Goldhaber (Author), Christian Pott (Author), Lars Eckardt (Author), Frank U. Müller (Author), Jan S. Schulte (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Principal mechanisms of arrhythmia have been derived from ventricular but not atrial cardiomyocytes of animal models despite higher prevalence of atrial arrhythmia (e.g., atrial fibrillation). Due to significant ultrastructural and functional differences, a simple transfer of ventricular...