Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors

• Main Authors: Peter Boknik (Author), Katharina Drzewiecki (Author), John Eskandar (Author), Ulrich Gergs (Author), Stephanie Grote-Wessels (Author), Larissa Fabritz (Author), Paulus Kirchhof (Author), Frank U. Müller (Author), Frank Stümpel (Author), Wilhelm Schmitz (Author), Norbert Zimmermann (Author), Uwe Kirchhefer (Author), Joachim Neumann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Adenosine can be produced in the heart and acts on cardiac adenosine receptors. One of these receptors is the A2A-adenosine receptor (A2A-AR).Methods and Results: To better understand its role in cardiac function, we generated and characterized mice (A2A-TG) which overexpress the human A...