Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors

• Главные авторы: Peter Boknik (Автор), Katharina Drzewiecki (Автор), John Eskandar (Автор), Ulrich Gergs (Автор), Stephanie Grote-Wessels (Автор), Larissa Fabritz (Автор), Paulus Kirchhof (Автор), Frank U. Müller (Автор), Frank Stümpel (Автор), Wilhelm Schmitz (Автор), Norbert Zimmermann (Автор), Uwe Kirchhefer (Автор), Joachim Neumann (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Предметы: article
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Background: Adenosine can be produced in the heart and acts on cardiac adenosine receptors. One of these receptors is the A2A-adenosine receptor (A2A-AR).Methods and Results: To better understand its role in cardiac function, we generated and characterized mice (A2A-TG) which overexpress the human A...