Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant <i>Escherichia coli</i>, In Vitro and in a Murine Peritonitis Model

• Main Authors: Samuel Chosidow (Author), Bruno Fantin (Author), Irène Nicolas (Author), Jean-Baptiste Mascary (Author), Françoise Chau (Author), Valérie Bordeau (Author), Marie-Clemence Verdier (Author), Pierre Rocheteau (Author), Francois Guérin (Author), Vincent Cattoir (Author), Victoire de Lastours (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colistin is a drug of last resort to treat extreme drug-resistant Enterobacterales, but is limited by dose-dependent toxicity and the emergence of resistance. A recently developed antimicrobial pseudopeptide, Pep16, which acts on the cell membrane, may be synergistic with colistin and limit the emer...