Investigation of the GnRH antagonist degarelix isomerization in biological matrices

• Main Authors: Lucia Ferrazzano (Author), Alessandra Tolomelli (Author), Ivan Guryanov (Author), Marco Macis (Author), Ulrich Abel (Author), Antonio Ricci (Author), Walter Cabri (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract One of the main objectives of peptide drug design is the improvement of peptide pharmacokinetics with maintaining biological activity, which can be achieved by the complex modifications of the primary structure of the peptides. However, these changes often lead to the formation of peculiar...