Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells

• Main Authors: Jiuhong Deng (Author), Chao Zheng (Author), Zhou Hua (Author), Haideng Ci (Author), Guiying Wang (Author), Lijing Chen (Author)
• Format: Book
• Published: BMC, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury. Methods First, we used CCK-8 to detect the effect of 0.1, 1, or...