Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids

• Main Authors: Michelle Wintzinger (Author), Manoj Panta (Author), Karen Miz (Author), Ashok D. Prabakaran (Author), Hima Bindu Durumutla (Author), Michelle Sargent (Author), Clara Bien Peek (Author), Joseph Bass (Author), Jeffery D. Molkentin (Author), Mattia Quattrocelli (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondrial capacity is critical to adapt the high energy demand of the heart to circadian oscillations and diseased states. Glucocorticoids regulate the circadian cycle of energy metabolism, but little is known about how circadian timing of exogenous glucocorticoid dosing directly regu...