Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

• 主要な著者: Qianqian Wang (著者), Jiahui Xu (著者), Ying Li (著者), Jumin Huang (著者), Zebo Jiang (著者), Yuwei Wang (著者), Liang Liu (著者), Elaine Lai Han Leung (著者), Xiaojun Yao (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone, which plays a key role in tumorigenesis. Many efforts have been taken in discovering small-molecular inhibitors against PRMT5, but very few...