Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

• Main Authors: Qianqian Wang (Author), Jiahui Xu (Author), Ying Li (Author), Jumin Huang (Author), Zebo Jiang (Author), Yuwei Wang (Author), Liang Liu (Author), Elaine Lai Han Leung (Author), Xiaojun Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone, which plays a key role in tumorigenesis. Many efforts have been taken in discovering small-molecular inhibitors against PRMT5, but very few...