Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

• Hlavní autoři: Yao Qi (Autor), Lin Guo (Autor), Yibing Jiang (Autor), Yijie Shi (Autor), Haijuan Sui (Autor), Liang Zhao (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

It is reported that quercetin (Que) can prevent tau pathology and induce neuroprotection by improving cognitive and functional symptoms in the treatment of Alzheimer's disease (AD). However, its clinical application has been limited due to its poor brain targeting and bioavailability. Exosomes...