Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation

• Main Authors: Susan J. Burke (Author), Heidi M. Batdorf (Author), David H. Burk (Author), Thomas M. Martin (Author), Tamra Mendoza (Author), Krisztian Stadler (Author), Wateen Alami (Author), Michael D. Karlstad (Author), Matthew J. Robson (Author), Randy D. Blakely (Author), Randall L. Mynatt (Author), J. Jason Collier (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pancreatic tissue, and islets in particular, are enriched in expression of the interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells are exquisitely sensitive to the IL-1R ligands IL-1α and IL-1β, suggesting that signaling through this pathway regulates health a...