Discovery of novel 2,4-diarylaminopyrimidine hydrazone derivatives as potent anti-thyroid cancer agents capable of inhibiting FAK

• Auteurs principaux: Hongting Li (Auteur), Mei-Qi Jia (Auteur), Zhao-Long Qin (Auteur), Changliang Lu (Auteur), Weili Chu (Auteur), Ze Zhang (Auteur), Jinbo Niu (Auteur), Jian Song (Auteur), Sai-Yang Zhang (Auteur), Lijun Fu (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TPC-1 cells, with IC50 values ranging from 0.113 to...