Discovery of novel 2,4-diarylaminopyrimidine hydrazone derivatives as potent anti-thyroid cancer agents capable of inhibiting FAK

• Main Authors: Hongting Li (Author), Mei-Qi Jia (Author), Zhao-Long Qin (Author), Changliang Lu (Author), Weili Chu (Author), Ze Zhang (Author), Jinbo Niu (Author), Jian Song (Author), Sai-Yang Zhang (Author), Lijun Fu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TPC-1 cells, with IC50 values ranging from 0.113 to...