AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?

• Main Authors: Federica Martorana (Author), Gianmarco Motta (Author), Giuliana Pavone (Author), Lucia Motta (Author), Stefania Stella (Author), Silvia Rita Vitale (Author), Livia Manzella (Author), Paolo Vigneri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including hormone receptor-positive (HR+) disease, HER2-ampli...