Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer's disease in APP/PS1 mice

• Main Authors: Shengnan Zhou (Author), Liwei Liu (Author), Yuanyuan Zhang (Author), Zhibo Zhang (Author), Hanbing Li (Author), Feng Fan (Author), Jiuming He (Author), Jian Kang (Author), Lihua Zuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction:Alpiniae oxyphyllae Fructus (AOF) has been abundantly utilized for the treatment of diarrhea, dyspepsia, kidney asthenia, and abdominal pain in China. AOF is effective for treating AD in clinical trials, but its exact mode of action is yet unknown.Methods: In this study, metabolomics wa...