EDP‐297: A novel, farnesoid X receptor agonist-Results of a phase I study in healthy subjects

• Main Authors: Christine Marotta (Author), Alaa Ahmad (Author), Ed Luo (Author), Jart Oosterhaven (Author), Sjoerd vanMarle (Author), Nathalie Adda (Author)
• Format: Bog
• Udgivet: Wiley, 2023-02-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract EDP‐297 is a farnesoid X receptor agonist under development for treating nonalcoholic steatohepatitis. The pharmacokinetic (PK), pharmacodynamic (PD), food effect, and safety were evaluated in a single ascending dose (SAD) and multiple ascending dose (MAD) phase I study. Healthy subjects re...