Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice

• Glavni autori: Jung-Yeon Kim (Autor), Jae-Hyung Park (Autor), Kiryeong Kim (Autor), Jungmin Jo (Autor), Jaechan Leem (Autor), Kwan-Kyu Park (Autor)
• Format: Knjiga
• Izdano: Hindawi Limited, 2018-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1β to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported that genetic deficiency of caspase-1 prevented cisplatin-ind...