Effects of Synthetic Sphingosine-1-Phosphate Analogs on Cytosolic Phospholipase A2α-Independent Release of Arachidonic Acid and Cell Toxicity in L929 Fibrosarcoma Cells: the Structure-Activity Relationship

• Main Authors: Masaya Shimizu (Author), Yuki Muramatsu (Author), Eiko Tada (Author), Takeshi Kurosawa (Author), Erika Yamaura (Author), Hiroyuki Nakamura (Author), Hiromichi Fujino (Author), Yuuya Houjyo (Author), Yuri Miyasaka (Author), Yuuki Koide (Author), Atsushi Nishida (Author), Toshihiko Murayama (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death. The development of analogs of S1P may be useful for regulating these...