Synthesis and Biological Evaluation of Structurally Varied 5'-/6'-Isonucleosides and Theobromine-Containing <i>N</i>-Isonucleosidyl Derivatives

• Hauptverfasser: Nuno M. Xavier (Verfasst von), Eduardo C. de Sousa (Verfasst von), Margarida P. Pereira (Verfasst von), Anne Loesche (Verfasst von), Immo Serbian (Verfasst von), René Csuk (Verfasst von), M. Conceição Oliveira (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2019-07-01T00:00:00Z.
• Schlagworte: article
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Isonucleosides are rather stable regioisomeric analogs of nucleosides with broad therapeutic potential. We have previously demonstrated the ability of 5′ and 6′-isonucleosides to inhibit the activity of acetylcholinesterase, a major target for Alzheimer’s disease therapy. Continuing with our researc...