The functional antagonist of sphingosine-1-phosphate, FTY720, impairs gut barrier function

• Main Authors: Sohini Sikdar (Author), Debmalya Mitra (Author), Oishika Das (Author), Moumita Bhaumik (Author), Shanta Dutta (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

FTY720 or fingolimod is a known functional antagonist of sphingosine-1-phosphate (S1P), and it is effective in treating multiple sclerosis and preventing inflammatory bowel disease (IBD). Evidence shows that its use in mice can increase the susceptibility to mucosal infections. Despite the significa...