Down-Regulation of Myosin Light Chain Kinase Expression in Vascular Smooth Muscle Cells Accelerates Cell Proliferation: Requirement of Its Actin-binding Domain for Reversion to Normal Rates

• Main Authors: Hong Hui Wang (Author), Akio Nakamura (Author), Shinji Yoshiyama (Author), Ryoki Ishikawa (Author), Na Cai (Author), Li-Hong Ye (Author), Hiromi Takano-Ohmuro (Author), Kazuhiro Kohama (Author)
• 格式: 图书
• 出版: Elsevier, 2012-01-01T00:00:00Z.
• 主题: article
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Myosin light-chain kinase (MLCK) is a multi-domain protein with kinase and actin-binding domains, among others. Deficiency of MLCK expression in GBaSM-4 vascular smooth muscle cells enhanced cell proliferation rate and shortened cell doubling time. Transient transfection of the MLCK-deficient cells...