β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

• Main Authors: Nina Suda (Author), Alberto Bartolomé (Author), Jiani Liang (Author), Jinsook Son (Author), Yoko Yagishita (Author), Christian Siebel (Author), Domenico Accili (Author), Hongxu Ding (Author), Utpal B. Pajvani (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Notch signaling, re-activated in β cells from obese mice and causal to β cell dysfunction, is determined in part by transmembrane ligand availability in a neighboring cell. We hypothesized that β cell expression of Jagged1 determines the maladaptive Notch response and resultant insulin se...