Mechanistic insight into the induction of cellular immune responses by encapsulated and admixed archaeosome-based vaccine formulations

• Main Authors: Gerard Agbayani (Author), Yimei Jia (Author), Bassel Akache (Author), Vandana Chandan (Author), Umar Iqbal (Author), Felicity C. Stark (Author), Lise Deschatelets (Author), Edmond Lam (Author), Usha D. Hemraz (Author), Sophie Régnier (Author), Lakshmi Krishnan (Author), Michael J. McCluskie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Archaeosomes are liposomes formulated using total polar lipids (TPLs) or semi-synthetic glycolipids derived from archaea. Conventional archaeosomes with entrapped antigen exhibit robust adjuvant activity as demonstrated by increased antigen-specific humoral and cell-mediated responses and enhanced p...