Exendin-4 Protects Against Sulfonylurea-Induced β-Cell Apoptosis

• Auteurs principaux: Ju-Young Kim (Auteur), Dong-Mee Lim (Auteur), Hyung-Seo Park (Auteur), Chan-Il Moon (Auteur), Kyung-Jin Choi (Auteur), Seong-Kyu Lee (Auteur), Haing-Woon Baik (Auteur), Keun-Young Park (Auteur), Byung-Joon Kim (Auteur)
• Format: Livre
• Publié: Elsevier, 2012-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Sulfonylurea is one of the commonly used anti-diabetic drugs that stimulate insulin secretion from β-cells. Despite their glucose lowering effects in type 2 diabetes mellitus, long-term treatment brought on secondary failure characterized by β-cell exhaustion and apoptosis. ER stress induced by Ca2+...