Exendin-4 Protects Against Sulfonylurea-Induced β-Cell Apoptosis

• Main Authors: Ju-Young Kim (Author), Dong-Mee Lim (Author), Hyung-Seo Park (Author), Chan-Il Moon (Author), Kyung-Jin Choi (Author), Seong-Kyu Lee (Author), Haing-Woon Baik (Author), Keun-Young Park (Author), Byung-Joon Kim (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulfonylurea is one of the commonly used anti-diabetic drugs that stimulate insulin secretion from β-cells. Despite their glucose lowering effects in type 2 diabetes mellitus, long-term treatment brought on secondary failure characterized by β-cell exhaustion and apoptosis. ER stress induced by Ca2+...