Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue

• Main Authors: Hsiao-Jou Cortina Chen (Author), Tsz Yip (Author), Johnny K. Lee (Author), Juliani Juliani (Author), Conrad Sernia (Author), Andrew F. Hill (Author), Nickolas A. Lavidis (Author), Jereme G. Spiers (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatic glutathione synthesis and antioxidant protection are critically important for efficient detoxification processes in response to metabolic challenges. However, this biosynthetic pathway, regulated by nuclear factor (erythroid-derived 2)-like 2 (Nrf2), previously demonstrated paradoxical repre...