A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

• Main Authors: Benedetta Gualeni (Author), M. Helen Rajpar (Author), Aaron Kellogg (Author), Peter A. Bell (Author), Peter Arvan (Author), Raymond P. Boot-Handford (Author), Michael D. Briggs (Author)
• Format: Book
• Published: The Company of Biologists, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival. Delineating the relative contribution of these two disease mechanisms is a major...