DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet

• Main Authors: Pili Zhang (Author), Tianjiao Chu (Author), N. Dedousis (Author), Benjamin S. Mantell (Author), Ian Sipula (Author), Lucy Li (Author), Kimberly D. Bunce (Author), Patricia A. Shaw (Author), Liora S. Katz (Author), Jun Zhu (Author), Carmen Argmann (Author), Robert M. O'Doherty (Author), David G. Peters (Author), Donald K. Scott (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Overnutrition can alter gene expression patterns through epigenetic mechanisms that may persist through generations. However, it is less clear if overnutrition, for example a high fat diet, modifies epigenetic control of gene expression in adults, or by what molecular mechanisms, or if su...