EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway

• Main Authors: Yongyun Li (Author), Tianyu Zhu (Author), Jie Yang (Author), Qianqian Zhang (Author), Shiqiong Xu (Author), Shengfang Ge (Author), Renbing Jia (Author), Jianming Zhang (Author), Xianqun Fan (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma (UM). Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular functions. In search of genetic vulnerability for UM, we found that inhibition of euchromatic histone lysin...