A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model.

• Main Authors: Rahsan Erdem (Author), Gwen Ambler (Author), Mohamed Al-Ibrahim (Author), Katarzyna Fraczek (Author), Steven D Dong (Author), Christopher Gast (Author), Laina D Mercer (Author), Michael Raine (Author), Sharon M Tennant (Author), Wilbur H Chen (Author), Eugenio L de Hostos (Author), Robert K M Choy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholera remains a major cause of infectious diarrhea globally. Despite the increased availability of cholera vaccines, there is still an urgent need for other effective interventions to reduce morbidity and mortality. Furthermore, increased prevalence of antibiotic-resistant Vibrio cholerae threaten...