A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model.

• المؤلفون الرئيسيون: Rahsan Erdem (مؤلف), Gwen Ambler (مؤلف), Mohamed Al-Ibrahim (مؤلف), Katarzyna Fraczek (مؤلف), Steven D Dong (مؤلف), Christopher Gast (مؤلف), Laina D Mercer (مؤلف), Michael Raine (مؤلف), Sharon M Tennant (مؤلف), Wilbur H Chen (مؤلف), Eugenio L de Hostos (مؤلف), Robert K M Choy (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2021-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Cholera remains a major cause of infectious diarrhea globally. Despite the increased availability of cholera vaccines, there is still an urgent need for other effective interventions to reduce morbidity and mortality. Furthermore, increased prevalence of antibiotic-resistant Vibrio cholerae threaten...