Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition

• Main Authors: Miho Kobayashi (Author), Kashio Fujiwara (Author), Kazuki Takahashi (Author), Yusuke Yoshioka (Author), Takahiro Ochiya (Author), Katarzyna A. Podyma-Inoue (Author), Tetsuro Watabe (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and metastatic potentials. Metastasis to distant organs requires intravascula...