Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis).

• Glavni autori: Gerritje J W van der Windt (Autor), W Joost Wiersinga (Autor), Catharina W Wieland (Autor), Ivo C S I Tjia (Autor), Nicholas P Day (Autor), Sharon J Peacock (Autor), Sandrine Florquin (Autor), Tom van der Poll (Autor)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2010-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Melioidosis, caused by infection with Burkholderia (B.) pseudomallei, is a severe illness that is endemic in Southeast Asia. Osteopontin (OPN) is a phosphorylated glycoprotein that is involved in several immune responses including induction of T-helper 1 cytokines and recruitment of inflammatory cel...