Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis).

• Main Authors: Gerritje J W van der Windt (Author), W Joost Wiersinga (Author), Catharina W Wieland (Author), Ivo C S I Tjia (Author), Nicholas P Day (Author), Sharon J Peacock (Author), Sandrine Florquin (Author), Tom van der Poll (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melioidosis, caused by infection with Burkholderia (B.) pseudomallei, is a severe illness that is endemic in Southeast Asia. Osteopontin (OPN) is a phosphorylated glycoprotein that is involved in several immune responses including induction of T-helper 1 cytokines and recruitment of inflammatory cel...