Enhancement of antifungal activity and transdermal delivery of 5-flucytosine via tailored spanlastic nanovesicles: statistical optimization, in-vitro characterization, and in-vivo biodistribution study

• Main Authors: Awaji Y. Safhi (Author), Nimbagal Raghavendra Naveen (Author), Krishna Jayanth Rolla (Author), Penmetsa Durga Bhavani (Author), Mallesh Kurakula (Author), Khaled M. Hosny (Author), Walaa A. Abualsunun (Author), Mohammed Alissa (Author), Abdullah Alsalhi (Author), Amerh Aiad Alahmadi (Author), Khalid Zoghebi (Author), Abdulrahman Sindam Halwaani (Author), Rasha Ibrahim K (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim and background: This current study aimed to load 5-flucytosine (5-FCY) into spanlastic nanovesicles (SPLNs) to make the drug more efficient as an antifungal and also to load the 5-FCY into a hydrogel that would allow for enhanced transdermal permeation and improved patient compliance.Methods: Th...