Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas.

• Main Authors: James I Dunlop (Author), Agnieszka M Szemiel (Author), Aitor Navarro (Author), Gavin S Wilkie (Author), Lily Tong (Author), Sejal Modha (Author), Daniel Mair (Author), Vattipally B Sreenu (Author), Ana Da Silva Filipe (Author), Ping Li (Author), Yan-Jang S Huang (Author), Benjamin Brennan (Author), Joseph Hughes (Author), Dana L Vanlandingham (Author), Stephen Higgs (Author), Richard M Elliott (Author), Alain Kohl (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Orthobunyaviruses such as Cache Valley virus (CVV) and Kairi virus (KRIV) are important animal pathogens. Periodic outbreaks of CVV have resulted in the significant loss of lambs on North American farms, whilst KRIV has mainly been detected in South and Central America with little overlap in geograp...