Nanoparticle‐mediated genome editing in single‐cell embryos via peptide nucleic acids

• Main Authors: Rachael Putman (Author), Adele S. Ricciardi (Author), Kelly E. W. Carufe (Author), Elias Quijano (Author), Raman Bahal (Author), Peter M. Glazer (Author), W. Mark Saltzman (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Through preimplantation genetic diagnosis, genetic diseases can be detected during the early stages of embryogenesis, but effective treatments for many of these disorders are lacking. Gene editing could allow for correction of the underlying mutation during embryogenesis to prevent disease...