Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth

• Main Authors: Luisa Maresca (Author), Enrica Crivaro (Author), Francesca Migliorini (Author), Giulia Anichini (Author), Alessandro Giammona (Author), Sara Pepe (Author), Federica Poggialini (Author), Chiara Vagaggini (Author), Giuseppe Giannini (Author), Serena Sestini (Author), Lorenzo Borgognoni (Author), Andrea Lapucci (Author), Elena Dreassi (Author), Maurizio Taddei (Author), Fabrizio Manetti (Author), Elena Petricci (Author), Barbara Stecca (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of Hedgehog (HH) signaling in cancer is the result of genetic alterations of upstream pathway components (canonical) or other oncogenic mechanisms (noncanonical), that ultimately concur to activate the zinc-finger transcription factors GLI1 and GLI2. Therefore, inhibition of GLI...