The NMR studies of CMP inhibition of polysialylation

• Main Authors: Bo Lu (Author), Si-Ming Liao (Author), Xue-Hui Liu (Author), Shi-Jie Liang (Author), Jun Huang (Author), Mei Lin (Author), Li Meng (Author), Qing-Yan Wang (Author), Ri-Bo Huang (Author), Guo-Ping Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The overexpression of polysialic acid (polySia) on neural cell adhesion molecules (NCAM) promotes hypersialylation, and thus benefits cancer cell migration and invasion. It has been proposed that the binding between the polysialyltransferase domain (PSTD) and CMP-Sia needs to be inhibited in order t...