Quantitative systems pharmacology model of erythropoiesis to simulate therapies targeting anemia due to chronic kidney disease

• Principais autores: Mrittika Roy (Autor), Shaifali Saroha (Autor), Uddipan Sarma (Autor), Harini Sarathy (Autor), Rukmini Kumar (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Anemia induced by chronic kidney disease (CKD) has multiple underlying mechanistic causes and generally worsens as CKD progresses. Erythropoietin (EPO) is a key endogenous protein which increases the number of erythrocyte progenitors that mature into red blood cells that carry hemoglobin (Hb). Recom...