Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study

• Main Authors: Steffen Hartleif (Author), Michael Schumm (Author), Michaela Döring (Author), Markus Mezger (Author), Peter Lang (Author), Marc H. Dahlke (Author), Joachim Riethmüller (Author), Alfred Königsrainer (Author), Rupert Handgretinger (Author), Silvio Nadalin (Author), Ekkehard Sturm (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. Mesenchymal stem (stromal) cells (MSC) have potent...