Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS

• Main Authors: Kai Hilpert (Author), Jurnorain Gani (Author), Christoph Rumancev (Author), Nathan Simpson (Author), Paula Matilde Lopez-Perez (Author), Vasil M. Garamus (Author), Andreas Robert von Gundlach (Author), Petar Markov (Author), Marco Scocchi (Author), Ralf Mikut (Author), Axel Rosenhahn (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH2 and Bac5-v291: RWRRPIRRRPIRPPFWR-CONH2) were comb...