Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

• Main Authors: Zhi Sun (Author), Jie Yang (Author), Liwei Liu (Author), Yanyan Xu (Author), Lin Zhou (Author), Qingquan Jia (Author), Yingying Shi (Author), Xiangyu Du (Author), Jian Kang (Author), Lihua Zuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trepibutone was widely used for cholelithiasis, cholecystitis, biliary tract dyskinesia, cholecystectomy syndrome, and chronic pancreatitis in clinic. However, few investigations on trepibutone have been conducted. In this study, an accurate, sensitive, and selective analytical method was developed...