Population Pharmacokinetics of Orally Administered Clindamycin to Treat Prosthetic Joint Infections: A Prospective Study

• Main Authors: Léo Mimram (Author), Sophie Magréault (Author), Younes Kerroumi (Author), Dominique Salmon (Author), Benjamin Kably (Author), Simon Marmor (Author), Anne-Sophie Jannot (Author), Vincent Jullien (Author), Valérie Zeller (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A population PK model of clindamycin orally administered to patients with prosthetic joint infections (PJIs) was developed using NONMEM 7.5. Monte-Carlo simulations were run to determine the probability of obtaining bone clindamycin concentrations equal to at least the MIC or four times the MIC for...