Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety

• Main Authors: Odilo Engel (Author), Aleksandar Masic (Author), Gary Landsberg (Author), Melissa Brooks (Author), Daniel S. Mills (Author), Chris Rundfeldt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Imepitoin is a low affinity partial agonist for the benzodiazepine binding site of γ-aminobutyric acid (GABAA) receptors, and is currently used as an antiepileptic in dogs. Here we tested imepitoin for anxiolytic properties. In an in vitro model, imepitoin was capable of preventing the effect of cor...