Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

• Main Authors: Gabriele Thumann (Author), Nina Harmening (Author), Cécile Prat-Souteyrand (Author), Corinne Marie (Author), Marie Pastor (Author), Attila Sebe (Author), Csaba Miskey (Author), Laurence D. Hurst (Author), Sabine Diarra (Author), Martina Kropp (Author), Peter Walter (Author), Daniel Scherman (Author), Zoltán Ivics (Author), Zsuzsanna Izsvák (Author), Sandra Johnen (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neovascular age-related macular degeneration (nvAMD) is characterized by choroidal blood vessels growing into the subretinal space, leading to retinal pigment epithelial (RPE) cell degeneration and vision loss. Vessel growth results from an imbalance of pro-angiogenic (e.g., vascular endothelial gro...