The treatment of severe child aggression (TOSCA) study: Design challenges

• Main Authors: Farmer Cristan A (Author), Arnold L Eugene (Author), Bukstein Oscar G (Author), Findling Robert L (Author), Gadow Kenneth D (Author), Li Xiaobai (Author), Butter Eric M (Author), Aman Michael G (Author)
• Format: Book
• Published: BMC, 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Polypharmacy (the concurrent use of more than one psychoactive drug) and other combination interventions are increasingly common for treatment of severe psychiatric problems only partly responsive to monotherapy. This practice and re...