Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells

• Main Authors: Adriana Trapani (Author), Stefano Castellani (Author), Lorenzo Guerra (Author), Elvira De Giglio (Author), Giuseppe Fracchiolla (Author), Filomena Corbo (Author), Nicola Cioffi (Author), Giuseppe Passantino (Author), Maria Luana Poeta (Author), Pasqualina Montemurro (Author), Rosanna Mallamaci (Author), Rosa Angela Cardone (Author), Massimo Conese (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson's disease (PD) treatment. In fact, GSE supply...