Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2

• Main Authors: Sinilnikova Olga (Author), McKay-Chopin Sandrine (Author), Forey Nathalie (Author), Michelon Jocelyne (Author), Jordheim Lars P (Author), Nguyen-Dumont Tú (Author), Le Calvez-Kelm Florence (Author), Southey Melissa C (Author), Tavtigian Sean V (Author), Lesueur Fabienne (Author)
• פורמט: ספר
• יצא לאור: BMC, 2011-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The gene <it>CHEK2 </it>encodes a checkpoint kinase playing a key role in the DNA damage pathway. Though <it>CHEK2 </it>has been identified as an intermediate breast cancer susceptibility gene, only a small pr...