Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction

• Main Authors: Chung-Hsi Hsing (Author), Shih-Kai Hung (Author), Yeong-Chang Chen (Author), Tsui-Shan Wei (Author), Ding-Ping Sun (Author), Jhi-Joung Wang (Author), Ching-Hua Yeh (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive production of cytokines by microglia may cause cognitive dysfunction and long-lasting behavioral changes. Activating the peripheral innate immune system stimulates cytokine secretion in the central nervous system, which modulates cognitive function. Histone deacetylases (HDACs) modulate cy...