Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase

• Main Authors: Itzhel García-Torres (Author), Ignacio De la Mora-De la Mora (Author), Gabriel López-Velázquez (Author), Nallely Cabrera (Author), Luis Antonio Flores-López (Author), Ingeborg Becker (Author), Juliana Herrera-López (Author), Roberto Hernández (Author), Ruy Pérez-Montfort (Author), Sergio Enríquez-Flores (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy. Previous studies have demonstrated the inhibition of triosephosphate isom...