Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

• Main Authors: Joaquim Aguirre-Plans (Author), Janet Piñero (Author), Jörg Menche (Author), Ferran Sanz (Author), Laura I. Furlong (Author), Harald H. H. W. Schmidt (Author), Baldo Oliva (Author), Emre Guney (Author)
• Format: Book
• Published: MDPI AG, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The past decades have witnessed a paradigm shift from the traditional drug discovery shaped around the idea of “one target, one disease” to polypharmacology (multiple targets, one disease). Given the lack of clear-cut boundaries across disease (endo)phenotypes and genetic heterogeneity across patien...