DNA methylation of SPARC and chronic low back pain

• Main Authors: Dashwood Thomas (Author), Millecamps Magali (Author), Alvarado Sebastian (Author), Tajerian Maral (Author), Anderson Kathleen M (Author), Haglund Lisbet (Author), Ouellet Jean (Author), Szyf Moshe (Author), Stone Laura S (Author)
• Format: Book
• Published: SAGE Publishing, 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein expression is decreased as a fu...